To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02320
Peptide Name pep42
Sequence CTVALPGGYVRVC
Sequence Length 13
UniProt ID No entry found
Taxon ID None
Source Designed In-silico [Pep42 cyclic peptide (CTVALPGGYVRVC) model was built using I-TASSER web server]
Validation In-Silico
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism EBOV
Assay N/A
Activity Not Available
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Cell-surface HSPA5
Mechanism Pep42 works against the Ebola virus by selectively targeting cell-surface HSPA5, also known as GRP78, which interacts with viral glycoproteins GP1 and GP2. By disrupting the interaction between HSPA5 and viral glycoproteins, Pep42 potentially inhibits viral entry into host cells, thereby reducing viral infection
Structure Information
PDB ID None
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C58H96N16O16S2
Absent amino acids DEFHIKMNOQSUW
Common amino acids V
Mass 1337.62
Pl 8.06
Basic residues 1
Acidic residues 0
Hydrophobic residues 5
Net charge 1
Boman Index -0.43
Hydrophobicity 1.1
Aliphatic Index 104.62
Half Life
Extinction Coefficient cystines 1615
Absorbance 280nm 1.207
Polar residues 5
Literature Information
Literature 1
Title Ebola virus glycoprotein GP1-host cell-surface HSPA5 binding site prediction.
Pubmed ID 32291698
Reference Cell Stress Chaperones. 2020;25(3):541-548
Author Elfiky AA, Elfiky AA
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.