To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02321
Peptide Name CP1
Sequence SGWIYWNV
Sequence Length 8
UniProt ID No entry found
Taxon ID None
Source Designed In-silico on VEGAZZ software
Validation In-Silico
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism EBOV
Assay N/A
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target VP40.
Mechanism The cyclic peptide CP1 works against Ebola virus by inhibiting the binding of the UEV domain protein to the Ebola Vp40 protein. This interference prevents the budding of the Ebola virus, thereby hindering its replication and spread. The specific residues Trp145, Tyr147, and Trp148 of CP1 play essential roles in the interactions between CP1 and the UEV domain protein, contributing to its inhibitory effect. By disrupting these protein-protein interactions crucial for virus budding, CP1 shows promise as a potential therapeutic agent against Ebola virus infections.
Structure Information
PDB ID None
Linear/Cyclic Cyclic
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C51H65N11O12
Absent amino acids ACDEFHKLMOPQRTU
Common amino acids W
Mass 1024.14
Pl 5.24
Basic residues 0
Acidic residues 0
Hydrophobic residues 4
Net charge 0
Boman Index -0.54
Hydrophobicity 0.113
Aliphatic Index 85
Half Life
Extinction Coefficient cystines 12490
Absorbance 280nm 12.196
Polar residues 3
Literature Information
Literature 1
Title Cyclic Peptide Inhibitors of the Tsg101 UEV Protein Interactions Refined through Global Docking and Gaussian Accelerated Molecular Dynamics Simulations
Pubmed ID 32998394
Reference Polymers (Basel). 2020;12(10)
Author Lin WW, Wang YJ, Ko CW, et al
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.