DRAVP ID  DRAVPe02322

Peptide Name   CP2

Sequence  SGWIAWNV

Sequence Length  8

UniProt ID  No entry found

Taxon ID  None

Source  Designed In-silico on VEGAZZ software

Validation   In-Silico

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  EBOV

Assay  N/A

Activity 

• [Ref:32998394]EBOV:IC50=296.3 microM

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  VP40.

Mechanism  CP2, a cyclic peptide inhibitor, has a weaker binding affinity for UEV domain proteins compared to CP1. Consequently, CP1 and CP3 are more effective at preventing UEV domain proteins from binding to the P6 motif, thereby inhibiting Ebola virus budding. In contrast, CP2's weaker binding suggests it is less potent in disrupting the necessary protein-protein interactions for virus budding inhibition.

PDB ID  None

Predicted Structure Download 

Linear/Cyclic  Cyclic

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Cyclic Peptide Inhibitors of the Tsg101 UEV Protein Interactions Refined through Global Docking and Gaussian Accelerated Molecular Dynamics Simulations

Pubmed ID   32998394

Reference   Polymers (Basel). 2020;12(10)

Author   Lin WW, Wang YJ, Ko CW, et al

DOI   10.3390/polym12102235