DRAVP ID  DRAVPe02324

Peptide Name   DFTavP1

Sequence  RWLRGLLSGLLRRLLSGLLL

Sequence Length  20

UniProt ID  No entry found

Taxon ID  None

Source  Designed In-silico (Ab-initio) by using database filtering technology

Validation   In-Silico

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  EBOV

Assay  N/A

Activity 

• [Ref:35631348]EBOV:IC50= 2.5 microM

Hemolytic Activity 

• [Ref:35631348]DFTavP1 displayed hemolytic activity, with an HC50 (the concentration that caused 50% hemolysis) below 12.5 microM. In contrast, DDIP1, another designed peptide, showed a higher HC50 val

Cytotoxicity 

• [Ref:35631348]DFTavP1 showed cytotoxic effects on Vero cells, with a TC50 (the peptide concentration that killed 50% of cells) of 2.4 microM. The peptide also exhibited cytotoxicity to Calu3 cells, wi

Binding Target  Viral envelopes.

Mechanism  DFTavP1 is a designed peptide that inhibits Ebola virus by blocking viral entry and disrupting viral envelopes, crucial steps in infection. Studies show DFTavP1 and similar peptides effectively inhibit pseudo-Ebola virus (VSV-eGP) in Vero cells, exhibiting dose-responsive inhibition even post-infection.

PDB ID  None

Predicted Structure Download 

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Improved Database Filtering Technology Enables More Efficient Ab Initio Design of Potent Peptides against Ebola Viruses.

Pubmed ID   35631348

Reference    Pharmaceuticals (Basel). 2022;15(5).

Author   Ripperda T, Yu Y, Verma A, et al.

DOI   10.3390/ph15050521