DRAVP ID  DRAVPe02327

Peptide Name   DDIP1

Sequence  GLRCRLGRLLRRLGRCLLR

Sequence Length  19

UniProt ID  No entry found

Taxon ID  None

Source  Designed In-silico (Ab-initio) by using database filtering technology

Validation   In-Silico

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  EBOV

Assay  N/A

Activity  Not Available

Hemolytic Activity 

• The hemolytic activity of DDIP1 was assessed using murine red blood cells, where the HC50 (concentration causing 50% hemolysis) was greater than 160 microM, indicating low hemolytic activity.

Cytotoxicity 

• [Ref:35631348]DDIP1 was evaluated for its cytotoxicity using various cell lines, including Vero cells and Calu3 cells. The results indicated that DDIP1 had a TC50 (toxic concentration at 50% cell deat

Binding Target  glycoprotein.

Mechanism   DDIP1, a database-designed inhibitory peptide, against Ebola virus. In experiments using an Ebola virus pseudo-type system, DDIP1 effectively inhibited the entry of pseudo-Ebola virus (VSV-eGP) into Vero cells at an early stage of infection. These findings suggest DDIP1's potential as a novel treatment for Ebola by targeting viral entry.

PDB ID  None

Predicted Structure Download 

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Improved Database Filtering Technology Enables More Efficient Ab Initio Design of Potent Peptides against Ebola Viruses.

Pubmed ID   35631348

Reference    Pharmaceuticals (Basel). 2022;15(5).

Author   Ripperda T, Yu Y, Verma A, et al.

DOI   10.3390/ph15050521