To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02329
Peptide Name eVpeD2
Sequence YYTRWQGGLRYIRPCG
Sequence Length 16
UniProt ID No entry found
Taxon ID None
Source Synthetic construct
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism EBOV
Assay N/A
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target VP24
Mechanism The macrocyclic peptide eVpeD2 exhibits potent binding to immobilized Zaire Ebola virus VP24, with a dissociation constant (KD) in the single-digit nanomolar range. Studies show that eVpeD2 disrupts the protein-protein interaction between eVP24 and KPNA5, confirmed through assays like the AlphaLISA-based binding assay. This inhibition suggests eVpeD2's potential as a modulator of a crucial interaction in Ebola virus pathogenesis.
Structure Information
PDB ID None
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Acetylation
Other Modification In the peptide sequence, the N-terminus is acetylated, and the tyrosine residue at position 1 is in the D-configuration
Stereochemistry L
Physicochemical Information
Formula C91H133N27O22S1
Absent amino acids ADEFHKMNOSUV
Common amino acids GRY
Mass 1989.28
Pl 9.78
Basic residues 3
Acidic residues 0
Hydrophobic residues 3
Net charge 3
Boman Index 2.31
Hydrophobicity -0.906
Aliphatic Index 48.75
Half Life
Extinction Coefficient cystines 9970
Absorbance 280nm 5.012
Polar residues 9
Literature Information
Literature 1
Title Macrocyclic peptide inhibitors for the protein-protein interaction of Zaire Ebola virus protein 24 and karyopherin alpha 5.
Pubmed ID 28574091
Reference Org Biomol Chem. 2017;15(24):5155-5160.
Author Song X, Lu LY, Passioura T, et al.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.