General Information


DRAVP ID  DRAVPe02331

Peptide Name   -

Sequence  CLHKPWSRC

Sequence Length  9

UniProt ID  No entry found

Taxon ID  None

Source  Phage display

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  SNV

Assay  Focus reduction assay

Activity 

  • [Ref:15919886]SNV:IC50=7.4 × 10^8particles/μl in Vero E6,89%,0.4629 (p value)inhibition in Vero E6 cells

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  beta-3 integrins

Mechanism  Blocking of SNV entry into Vero E6 cells



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Cyclic 

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H49C74N16O10S2

Absent amino acids  ADEFGIMNQTVY

Common amino acids  CHKLPRSW

Mass  1129.3584

Pl  8.95718898773193

Basic residues  3

Acidic residues  0

Hydrophobic residues  4

Net charge  1.82646482134686

Boman Index  1.373

Hydrophobicity  -0.677777777777777

Aliphatic Index  43.33

Half Life 

  •     Mammalian:1.2 hours
  •     Yeast:1 hours
  •     E.coli:1.1 hours

Extinction Coefficient cystines  5500

Absorbance 280nm  4.87002177519554

Polar residues  5



Literature Information


Literature 1

Title   Peptide antagonists that inhibit Sin Nombre virus and hantaan virus entry through the beta3-integrin receptor.

Pubmed ID   15919886

Reference   J Virol. 2005

Author   Larson RS, Brown DC, Ye C, Hjelle B.

DOI   10.1128/JVI.79.12.7319-7326.2005