General Information


DRAVP ID  DRAVPe02334

Peptide Name   -

Sequence  CNHTRNMAC

Sequence Length  9

UniProt ID  No entry found

Taxon ID  None

Source  Phage display

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  SNV

Assay  Focus reduction assay

Activity 

  • [Ref:15919886]SNVV:IC50=29% in Vero E6

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  beta-3 integrins

Mechanism  Blocking of SNV entry into Vero E6 cells



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Cyclic 

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H75C111N20O23S0

Absent amino acids  CDHKLMSW

Common amino acids  AEFGINPQRTVY

Mass  1679.82699999999

Pl  4.53139781951904

Basic residues  1

Acidic residues  2

Hydrophobic residues  6

Net charge  -1.23528646276327

Boman Index  0.894

Hydrophobicity  -0.36

Aliphatic Index  71.33

Half Life 

  •     Mammalian:1.0 hours
  •     Yeast:1 hours
  •     E.coli:1 hours

Extinction Coefficient cystines  1490

Absorbance 280nm  0.88699610138425

Polar residues  9



Literature Information


Literature 1

Title   Peptide antagonists that inhibit Sin Nombre virus and hantaan virus entry through the beta3-integrin receptor.

Pubmed ID   15919886

Reference   J Virol. 2005

Author   Larson RS, Brown DC, Ye C, Hjelle B.

DOI   10.1128/JVI.79.12.7319-7326.2005