General Information


DRAVP ID  DRAVPe02337

Peptide Name   -

Sequence  COPHTLPTC

Sequence Length  9

UniProt ID  No entry found

Taxon ID  None

Source  Phage display

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  SNV

Assay  Focus reduction assay

Activity 

  • [Ref:15919886]SNV:59%,0.0001(p value) inhibition in Vero E6 cells

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  beta-3 integrins

Mechanism  Blocking of SNV entry into Vero E6 cells



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Cyclic 

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H44C64N10O15S4

Absent amino acids  ADFGHIKLNPQRVY

Common amino acids  CEMSTW

Mass  1119.3122

Pl  4.05002841949462

Basic residues  0

Acidic residues  2

Hydrophobic residues  5

Net charge  -2.25407944206229

Boman Index  0.971

Hydrophobicity  -0.0666666666666667

Aliphatic Index  0

Half Life 

  •     Mammalian:1.2 hours
  •     Yeast:1 hours
  •     E.coli:1.1 hours

Extinction Coefficient cystines  5500

Absorbance 280nm  4.91373184353749

Polar residues  4



Literature Information


Literature 1

Title   Peptide antagonists that inhibit Sin Nombre virus and hantaan virus entry through the beta3-integrin receptor.

Pubmed ID   15919886

Reference   J Virol. 2005

Author   Larson RS, Brown DC, Ye C, Hjelle B.

DOI   10.1128/JVI.79.12.7319-7326.2005