General Information


DRAVP ID  DRAVPe02353

Peptide Name   -

Sequence  CPFVKTQLC

Sequence Length  9

UniProt ID  No entry found

Taxon ID  None

Source  Phage display

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  SNV

Assay  Focus reduction assay

Activity 

  • [Ref:15919886]SNV:IC50=2.7 × 10^8 particles/μl,91%,0.0147 inhibition in Vero E6 cells

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  beta-3 integrins

Mechanism  Blocking of SNV entry into Vero E6 cells



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Cyclic 

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H146C241N47O31S1

Absent amino acids  DEKMQWY

Common amino acids  ACFGHILNPRSTV

Mass  3200.85189999999

Pl  11.9999677658081

Basic residues  7

Acidic residues  0

Hydrophobic residues  14

Net charge  4.2101104426431

Boman Index  0.902

Hydrophobicity  0.492857142857142

Aliphatic Index  138.93

Half Life 

  •     Mammalian:20 hours
  •     Yeast:15 hours
  •     E.coli:18 hours

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  14



Literature Information


Literature 1

Title   Peptide antagonists that inhibit Sin Nombre virus and hantaan virus entry through the beta3-integrin receptor.

Pubmed ID   15919886

Reference   J Virol. 2005

Author   Larson RS, Brown DC, Ye C, Hjelle B.

DOI   10.1128/JVI.79.12.7319-7326.2005