General Information


DRAVP ID  DRAVPe02367

Peptide Name   -

Sequence  CLALNMSYC

Sequence Length  9

UniProt ID  No entry found

Taxon ID  None

Source  Phage display

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  SNV

Assay  Focus reduction assay

Activity 

  • [Ref:15919886]SNV:58%,0.0044 (p value)inhibition in Vero E6 cells

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  beta-3 integrins

Mechanism  Blocking of SNV entry into Vero E6 cells



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Cyclic 

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H75C138N24O18S0

Absent amino acids  ACDEFHMNPQTWY

Common amino acids  GIKLRSV

Mass  1682.0632

Pl  11.9999677658081

Basic residues  4

Acidic residues  0

Hydrophobic residues  7

Net charge  3.73197038815714

Boman Index  0.794

Hydrophobicity  0.64375

Aliphatic Index  151.87

Half Life 

  •     Mammalian:100 hours
  •     Yeast:60 hours
  •     E.coli:90 hours

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  9



Literature Information


Literature 1

Title   Peptide antagonists that inhibit Sin Nombre virus and hantaan virus entry through the beta3-integrin receptor.

Pubmed ID   15919886

Reference   J Virol. 2005

Author   Larson RS, Brown DC, Ye C, Hjelle B.

DOI   10.1128/JVI.79.12.7319-7326.2005