General Information


DRAVP ID  DRAVPe02372

Peptide Name   -

Sequence  CLTDRHRTC

Sequence Length  9

UniProt ID  No entry found

Taxon ID  None

Source  Phage display

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  SNV

Assay  Focus reduction assay

Activity 

  • [Ref:15919886]SNV:IC50=39%,0.3065(p value) inhibition in Vero E6 cells

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  beta-3 integrins

Mechanism  Blocking of SNV entry into Vero E6 cells



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Cyclic 

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H86C139N23O25S0

Absent amino acids  CEFHIMNQSY

Common amino acids  ADGKLPRTVW

Mass  1913.17819999999

Pl  8.74773120880127

Basic residues  2

Acidic residues  1

Hydrophobic residues  7

Net charge  0.760213374230145

Boman Index  0.668

Hydrophobicity  0.00555555555555558

Aliphatic Index  81.11

Half Life 

  •     Mammalian:2.8 hours
  •     Yeast:2.5 hours
  •     E.coli:2.6 hours

Extinction Coefficient cystines  5500

Absorbance 280nm  2.87479754891625

Polar residues  11



Literature Information


Literature 1

Title   Peptide antagonists that inhibit Sin Nombre virus and hantaan virus entry through the beta3-integrin receptor.

Pubmed ID   15919886

Reference   J Virol. 2005

Author   Larson RS, Brown DC, Ye C, Hjelle B.

DOI   10.1128/JVI.79.12.7319-7326.2005