General Information


DRAVP ID  DRAVPe02482

Peptide Name   -

Sequence  RADITTVSTFIDLNI

Sequence Length  15

UniProt ID  P06437 

Taxon ID  10306 

Source  Synthetic construct(derived from HSV-1 B glycoprotein (gB))

Validation   Experimentally Validated



Origin Information


Gene Name/ID  gB

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  K01760 

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  HSV

Assay  beta-galactosidase activity

Activity 

  • [Ref:19104014]HSV-1:IC50=Low in Vero cells

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Virus entry

Mechanism  Not Available



Structure Information


PDB ID  2GUM  3NW8 

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H35C60N12O10S2

Absent amino acids  BEGHJKMOQSWXY

Common amino acids  RA

Mass  891.0705

Pl  8.07210254669189

Basic residues  1

Acidic residues  0

Hydrophobic residues  4

Net charge  0.740289634091281

Boman Index  0.512

Hydrophobicity  0.588888888888888

Aliphatic Index  75.56

Half Life 

  •     Mammalian:7.2 hour
  •     Yeast:>20 hours
  •     E.coli:>10 hours

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  5



Literature Information


Literature 1

Title   Multiple peptides homologous to herpes simplex virus type 1 glycoprotein B inhibit viral infection.

Pubmed ID   19104014

Reference   Antimicrob Agents Chemother. 2009

Author   Akkarawongsa R, Pocaro NE, Case G, Kolb AW, Brandt CR.

DOI   10.1128/AAC.00793-08