General Information


DRAVP ID  DRAVPe02594

Peptide Name   -

Sequence  VCRSTAKYVRNNLET

Sequence Length  15

UniProt ID  P06437 

Taxon ID  10306 

Source  Synthetic construct(derived from HSV-1 B glycoprotein (gB))

Validation   Experimentally Validated



Origin Information


Gene Name/ID  gB

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  K01760 

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  HSV

Assay  beta-galactosidase activity

Activity 

  • [Ref:19104014]HSV-1:IC50=Low in Vero cells

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Virus entry

Mechanism  Not Available



Structure Information


PDB ID  2GUM  3NW8 

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H35C57N7O9S0

Absent amino acids  BCDFGHIJKLMNOPQRSW

Common amino acids  VC

Mass  737.8838

Pl  8.59087963104248

Basic residues  1

Acidic residues  0

Hydrophobic residues  3

Net charge  0.758103612191301

Boman Index  0.968

Hydrophobicity  0.166666666666666

Aliphatic Index  130

Half Life 

  •     Mammalian:7.2 hour
  •     Yeast:>20 hours
  •     E.coli:>10 hours

Extinction Coefficient cystines  1490

Absorbance 280nm  2.01928813181696

Polar residues  3



Literature Information


Literature 1

Title   Multiple peptides homologous to herpes simplex virus type 1 glycoprotein B inhibit viral infection.

Pubmed ID   19104014

Reference   Antimicrob Agents Chemother. 2009

Author   Akkarawongsa R, Pocaro NE, Case G, Kolb AW, Brandt CR.

DOI   10.1128/AAC.00793-08