To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02601
Peptide Name 139-153
Sequence GRKRRQTSMTDFYHS
Sequence Length 15
UniProt ID P38936
Taxon ID 9606
Source Host p21 protein
Validation Experimentally Validated
Origin Information
Gene Name/ID CDKN1A
GenBank Not Available
Amino Acid position 139-153
Domain Accession ID Not Available
Nucleotide sequence ID CM000668.2
Molecular Type Not Available
Chromosomal Position Chromosome 6: 36,676,460-36,687,397
Activity Information
Target Organism HCV
Assay EMSA
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target NS5A protein
Mechanism Peptide derived from the C-terminal end of NS5A protein moderately inhibits the assembly process.Exerts viral interference on hepatitis B virus when HCV and HBV coinfect the same cell, by suppressing HBV gene expression, RNA encapsidation and budding.
Structure Information
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula H42C61N13O12S2
Absent amino acids ABCEIJLNPVWXZ
Common amino acids GR
Mass 1022.15889999999
Pl 8.054953956604
Basic residues 2
Acidic residues 0
Hydrophobic residues 4
Net charge 0.825475820247868
Boman Index 1.06
Hydrophobicity -0.833333333333333
Aliphatic Index 11.11
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 1.45769899376702
Polar residues 5
Literature Information
Literature 1
Title Interfering with hepatitis C virus assembly in vitro using affinity peptides directed towards core protein.
Pubmed ID 22452666
Reference Can J Microbiol. 2012
Author Duvignaud JB, Majeau N, Delisle P, Voyer N, Gagne SM, Leclerc D.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.