To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02606
Peptide Name 336-350
Sequence VKKRRHGDEDMFYMH
Sequence Length 15
UniProt ID Q9JJP2
Taxon ID 10090
Source Host p73 protein
Validation Experimentally Validated
Origin Information
Gene Name/ID Tp73
GenBank Not Available
Amino Acid position 336-350
Domain Accession ID Not Available
Nucleotide sequence ID CM000997.3
Molecular Type Not Available
Chromosomal Position Chromosome 4: 154,140,706-154,224,665
Activity Information
Target Organism HCV
Assay EMSA
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target NS5A protein
Mechanism Peptide derived from the C-terminal end of NS5A protein moderately inhibits the assembly process.Exerts viral interference on hepatitis B virus when HCV and HBV coinfect the same cell, by suppressing HBV gene expression, RNA encapsidation and budding.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula H168C272N42O57S0
Absent amino acids ABCIJLNPQSTWXZ
Common amino acids VK
Mass 3810.2194
Pl 4.1967866897583
Basic residues 3
Acidic residues 7
Hydrophobic residues 13
Net charge -4.02986400470627
Boman Index 0.987
Hydrophobicity -0.373529411764705
Aliphatic Index 117.65
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 1.44348643020399
Polar residues 21
Literature Information
Literature 1
Title Interfering with hepatitis C virus assembly in vitro using affinity peptides directed towards core protein.
Pubmed ID 22452666
Reference Can J Microbiol. 2012
Author Duvignaud JB, Majeau N, Delisle P, Voyer N, Gagne SM, Leclerc D.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.