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General Information
DRAVP ID DRAVPe02611
Peptide Name 321-335
Sequence AFKQSPPAIPALGTN
Sequence Length 15
UniProt ID Q9JJP2
Taxon ID 10090
Source Host p73 protein
Validation Experimentally Validated
Origin Information
Gene Name/ID Tp73
GenBank Not Available
Amino Acid position 321-335
Domain Accession ID Not Available
Nucleotide sequence ID CM000997.3
Molecular Type Not Available
Chromosomal Position Chromosome 4: 154,140,706-154,224,665
Activity Information
Target Organism HCV
Assay EMSA
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target NS5A protein
Mechanism Peptide derived from the C-terminal end of NS5A protein moderately inhibits the assembly process.Exerts viral interference on hepatitis B virus when HCV and HBV coinfect the same cell, by suppressing HBV gene expression, RNA encapsidation and budding.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula H89C130N18O22S1
Absent amino acids BCDEHJMQRVWXZ
Common amino acids AF
Mass 1854.1719
Pl 9.34793186187744
Basic residues 3
Acidic residues 1
Hydrophobic residues 8
Net charge 1.95365562252419
Boman Index 1.139
Hydrophobicity -0.479999999999999
Aliphatic Index 45.33
Half Life
Extinction Coefficient cystines 4470
Absorbance 280nm 2.41077971249591
Polar residues 7
Literature Information
Literature 1
Title Interfering with hepatitis C virus assembly in vitro using affinity peptides directed towards core protein.
Pubmed ID 22452666
Reference Can J Microbiol. 2012
Author Duvignaud JB, Majeau N, Delisle P, Voyer N, Gagne SM, Leclerc D.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.