DRAVP ID  DRAVPe02616

Peptide Name   150-164

Sequence  FYHSKRRLIFSKRKP

Sequence Length  15

UniProt ID  P38936 

Taxon ID  9606 

Source  Host p21 protein

Validation   Experimentally Validated

Gene Name/ID  CDKN1A

GenBank  Not Available

Amino Acid position  150-164

Domain Accession ID  Not Available

Nucleotide sequence ID  CM000668.2 

Molecular Type  Not Available

Chromosomal Position  Chromosome 6: 36,676,460-36,687,397

Target Organism  HCV

Assay  EMSA

Activity 

• [Ref:22452666]HCV:IC50=decrease the initial rate and maximum OD strongly to levels as low as 87% and 89%,respectively.

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  NS5A protein

Mechanism  Peptide derived from the C-terminal end of NS5A protein moderately inhibits the assembly process.Exerts viral interference on hepatitis B virus when HCV and HBV coinfect the same cell, by suppressing HBV gene expression, RNA encapsidation and budding.

PDB ID  1AXC  2ZVV 

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Interfering with hepatitis C virus assembly in vitro using affinity peptides directed towards core protein.

Pubmed ID   22452666

Reference   Can J Microbiol. 2012

Author   Duvignaud JB, Majeau N, Delisle P, Voyer N, Gagne SM, Leclerc D.

DOI   10.1139/w2012-009