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General Information
DRAVP ID DRAVPe02617
Peptide Name 324-338
Sequence QSPPAIPALGTNVKK
Sequence Length 15
UniProt ID Q9JJP2
Taxon ID 10090
Source Host p73 protein
Validation Experimentally Validated
Origin Information
Gene Name/ID Tp73
GenBank Not Available
Amino Acid position 324-338
Domain Accession ID Not Available
Nucleotide sequence ID CM000997.3
Molecular Type Not Available
Chromosomal Position Chromosome 4: 154,140,706-154,224,665
Activity Information
Target Organism HCV
Assay EMSA
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target NS5A protein
Mechanism Peptide derived from the C-terminal end of NS5A protein moderately inhibits the assembly process.Exerts viral interference on hepatitis B virus when HCV and HBV coinfect the same cell, by suppressing HBV gene expression, RNA encapsidation and budding.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula H18C29N7O4S0
Absent amino acids BCDEHJMRWXZ
Common amino acids QS
Mass 425.482699999999
Pl 9.75002117156982
Basic residues 1
Acidic residues 0
Hydrophobic residues 0
Net charge 0.760091614289301
Boman Index 0.868
Hydrophobicity -2.025
Aliphatic Index 0
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Literature Information
Literature 1
Title Interfering with hepatitis C virus assembly in vitro using affinity peptides directed towards core protein.
Pubmed ID 22452666
Reference Can J Microbiol. 2012
Author Duvignaud JB, Majeau N, Delisle P, Voyer N, Gagne SM, Leclerc D.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.