To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02620
Peptide Name 148-165
Sequence ARALAHGVRVLEDGVNYA
Sequence Length 18
UniProt ID P27958
Taxon ID 63746
Source HCV core protein
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position 148-165
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism HCV
Assay EMSA
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target NS5A protein
Mechanism Peptide derived from the C-terminal end of NS5A protein moderately inhibits the assembly process.Exerts viral interference on hepatitis B virus when HCV and HBV coinfect the same cell, by suppressing HBV gene expression, RNA encapsidation and budding.
Structure Information
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula H96C131N29O27S1
Absent amino acids BCIJKMQWXZ
Common amino acids AR
Mass 2175.3415
Pl 6.9094274520874
Basic residues 3
Acidic residues 1
Hydrophobic residues 5
Net charge -0.0743402383606897
Boman Index 1.103
Hydrophobicity -1.04444444444444
Aliphatic Index 21.67
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 2.52833865395387
Polar residues 13
Literature Information
Literature 1
Title Interfering with hepatitis C virus assembly in vitro using affinity peptides directed towards core protein.
Pubmed ID 22452666
Reference Can J Microbiol. 2012
Author Duvignaud JB, Majeau N, Delisle P, Voyer N, Gagne SM, Leclerc D.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.