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General Information
DRAVP ID DRAVPe02623
Peptide Name 2395-2412
Sequence PGDPDLSDGSWSTVSSGA
Sequence Length 18
UniProt ID P27958
Taxon ID 63746
Source HCV non-structural protein 5A
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position 2395-2412
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism HCV
Assay EMSA
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target NS5A protein
Mechanism Peptide derived from the C-terminal end of NS5A protein moderately inhibits the assembly process.Exerts viral interference on hepatitis B virus when HCV and HBV coinfect the same cell, by suppressing HBV gene expression, RNA encapsidation and budding.
Structure Information
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula H170C279N48O58S0
Absent amino acids BCHJKMQXZ
Common amino acids PG
Mass 3942.3441
Pl 4.76710910797119
Basic residues 6
Acidic residues 8
Hydrophobic residues 11
Net charge -2.19241652428969
Boman Index 1.206
Hydrophobicity -0.964705882352941
Aliphatic Index 97.65
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 1.39510906721714
Polar residues 23
Literature Information
Literature 1
Title Interfering with hepatitis C virus assembly in vitro using affinity peptides directed towards core protein.
Pubmed ID 22452666
Reference Can J Microbiol. 2012
Author Duvignaud JB, Majeau N, Delisle P, Voyer N, Gagne SM, Leclerc D.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.