DRAVP ID  DRAVPe02628

Peptide Name   120-137

Sequence  GKVIDTLTCGFADLMGYI

Sequence Length  18

UniProt ID  P27958 

Taxon ID  63746 

Source  HCV core protein

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  120-137

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  HCV

Assay  EMSA

Activity 

• [Ref:22452666]HCV:IC50=decrease the initial rate and maximum OD strongly to levels as low as 40% and 69%,respectively.

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  NS5A protein

Mechanism  Peptide derived from the C-terminal end of NS5A protein moderately inhibits the assembly process.Exerts viral interference on hepatitis B virus when HCV and HBV coinfect the same cell, by suppressing HBV gene expression, RNA encapsidation and budding.

PDB ID  1A1R  1A1V 

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Interfering with hepatitis C virus assembly in vitro using affinity peptides directed towards core protein.

Pubmed ID   22452666

Reference   Can J Microbiol. 2012

Author   Duvignaud JB, Majeau N, Delisle P, Voyer N, Gagne SM, Leclerc D.

DOI   10.1139/w2012-009