General Information


DRAVP ID  DRAVPe02645

Peptide Name   A7

Sequence  RRKKAAVALLPAVKLALLAP

Sequence Length  20

UniProt ID  P08620 

Taxon ID  9606 

Source  Synthetic construct(derived from FGF-4 signal sequence)

Validation   Experimentally Validated



Origin Information


Gene Name/ID  FGF4/2249

GenBank  AAB59555.1

Amino Acid position  Not Available

Domain Accession ID  AAA59473.1 

Nucleotide sequence ID  CM000673.2 

Molecular Type  Genomic DNA

Chromosomal Position  Chromosome 11: 69,773,312-69,775,098



Activity Information


Target Organism  VACV

Assay  Plaque assay

Activity 

  • [Ref:19395056]VACV:EC50=-0.03µM mOD/min in Hela cells

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Membrane

Mechanism  Inhibit Virus entry



Structure Information


PDB ID  1IJT 

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H12C17N3O3S0

Absent amino acids  FHIMTW

Common amino acids  RLA

Mass  269.296999999999

Pl  5.95498714447021

Basic residues  0

Acidic residues  0

Hydrophobic residues  0

Net charge  -0.0414711324216447

Boman Index  0.303

Hydrophobicity  -1.2

Aliphatic Index  0

Half Life 

  •     Mammalian:20hours
  •     Yeast:15hours
  •     E.coli:18hours

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  3



Literature Information


Literature 1

Title   Inhibition of Vaccinia virus entry by a broad spectrum antiviral peptide.

Pubmed ID   19395056

Reference   Virology. 2009

Author   Altmann SE, Jones JC, Schultz-Cherry S, Brandt CR.

DOI    10.1016/j.virol.2009.03.023