General Information


DRAVP ID  DRAVPe02648

Peptide Name   GFP-NP9-5

Sequence  PPWCCCSPMKRASPPPAQSDLPATPKCPP

Sequence Length  29

UniProt ID  No Entry Found 

Taxon ID  None

Source  Synthetic Contrust (from Conotoxin)

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  IAV

Assay  Luciferase assay

Activity 

  • [Ref:22095520]IAV:IC50=40.7% ±15.8%,multiplicity of infection of 0.01 was inhibited to 20% and 69% at 12 and 24 h post-infection, respectively.

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Nucleoprotein

Mechanism  Inhibit Replication



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H39C63N15O12S3

Absent amino acids  NYOUM

Common amino acids  PCL

Mass  1048.2211

Pl  8.08164386749267

Basic residues  2

Acidic residues  0

Hydrophobic residues  3

Net charge  2

Boman Index  0.901

Hydrophobicity  -0.822222222222222

Aliphatic Index  0

Half Life 

  •     Mammalian:1.2hours
  •     Yeast:1hours
  •     E.coli:1.1hours

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  6



Literature Information


Literature 1

Title   Inhibition of influenza virus replication by constrained peptides targeting nucleoprotein.

Pubmed ID   22095520

Reference   Antivir Chem Chemother. 2011

Author   Jiang H, Xu Y, Li L, Weng L, Wang Q, Zhang S, Jia B, Hu H, He Y, Jacob Y, Toyoda T.

DOI   10.3851/IMP1902