To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02653
Peptide Name Inhibitor 2
Sequence CGYGLC
Sequence Length 6
UniProt ID No Entry Found
Taxon ID None
Source Synthetic-Contruct
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism DENV 2
Assay Flouroscence spectrtophotometery
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Membrane
Mechanism Inhibit Replication
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula H169C277N45O57S0
Absent amino acids RNDQWVOU
Common amino acids CG
Mass 3869.28989999999
Pl 4.44119434356689
Basic residues 4
Acidic residues 7
Hydrophobic residues 13
Net charge -3.22830125799532
Boman Index 1.049
Hydrophobicity -0.458823529411764
Aliphatic Index 117.65
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 1.42144944993654
Polar residues 21
Literature Information
Literature 1
Title Critical effect of peptide cyclization on the potency of peptide inhibitors against Dengue virus NS2B-NS3 protease.
Pubmed ID 22780881
Reference J Med Chem. 2012
Author Xu S, Li H, Shao X, Fan C, Ericksen B, Liu J, Chi C, Wang C.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.