General Information


DRAVP ID  DRAVPe02662

Peptide Name   -

Sequence  AYQPLLSNTLAELYV

Sequence Length  15

UniProt ID  P06437 

Taxon ID  10306 

Source  HSV-1 B glycoprotein (gB)

Validation   Experimentally Validated



Origin Information


Gene Name/ID  gB

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  K01760 

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  HSV 1

Assay  beta-galactosidase activity

Activity 

  • [Ref:19104014] HSV-1:IC50=Low in Vero cells

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Membrane

Mechanism  Inhibit Virus entry



Structure Information


PDB ID  2GUM  3NW8 

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H84C133N17O14S0

Absent amino acids  HIKMFTWV

Common amino acids  LA

Mass  1623.0754

Pl  10.4777402877807

Basic residues  4

Acidic residues  0

Hydrophobic residues  7

Net charge  3.75610561019329

Boman Index  1.34

Hydrophobicity  0.438461538461538

Aliphatic Index  120

Half Life 

  •     Mammalian:1.3hours
  •     Yeast:1.1hours
  •     E.coli:1.2hours

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  6



Literature Information


Literature 1

Title   Multiple peptides homologous to herpes simplex virus type 1 glycoprotein B inhibit viral infection.

Pubmed ID   19104014

Reference   Antimicrob Agents Chemother. 2009

Author   Akkarawongsa R, Pocaro NE, Case G, Kolb AW, Brandt CR.

DOI   10.1128/AAC.00793-08