General Information


DRAVP ID  DRAVPe02664

Peptide Name   C8

Sequence  CRCCELKSLCPTLMRVVRLLGLVLL

Sequence Length  25

UniProt ID  No Entry Found 

Taxon ID  None

Source  Synthetic-Contruct

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  RV

Assay  GFP assay

Activity 

  • [Ref:15220414]HCV:IC50=78% in BSR cells

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Phosphoprotein

Mechanism  Not Available



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H202C310N51O59S0

Absent amino acids  HIMFTW

Common amino acids  CLR

Mass  4417.9677

Pl  4.76801853179931

Basic residues  5

Acidic residues  7

Hydrophobic residues  15

Net charge  -2.22960855995896

Boman Index  1.343

Hydrophobicity  -0.827777777777777

Aliphatic Index  108.33

Half Life 

  •     Mammalian:20hours
  •     Yeast:15hours
  •     E.coli:18hours

Extinction Coefficient cystines  13980

Absorbance 280nm  3.16435088468392

Polar residues  21



Literature Information


Literature 1

Title   Antiviral drug discovery strategy using combinatorial libraries of structurally constrained peptides.

Pubmed ID   15220414

Reference   J Virol. 2004

Author   Real E, Rain JC, Battaglia V, Jallet C, Perrin P, Tordo N, Chrisment P, D'Alayer J, Legrain P, Jacob Y.

DOI   10.1128/JVI.78.14.7410-7417.2004