General Information


DRAVP ID  DRAVPe02666

Peptide Name   P4

Sequence  KNEWGCRCNDSSDGNEWGCRCNDSSD

Sequence Length  26

UniProt ID  P0DOF5 

Taxon ID  381517 

Source  INFV A matrix protein 2

Validation   Experimentally Validated



Origin Information


Gene Name/ID  M

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  INFV A

Assay  ELISA

Activity 

  • [Ref:12628550]IAV:IC50=Low in MDCK cells

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Membrane

Mechanism  Inhibit Replication



Structure Information


PDB ID  1MP6  2KIH 

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H75C112N18O22S1

Absent amino acids  HILMFTV

Common amino acids  CDS

Mass  1667.87919999999

Pl  5.0764268875122

Basic residues  1

Acidic residues  1

Hydrophobic residues  9

Net charge  -1.16250342771427

Boman Index  0.663

Hydrophobicity  0.813333333333333

Aliphatic Index  110.67

Half Life 

  •     Mammalian:3.5hours
  •     Yeast:4hours
  •     E.coli:3hours

Extinction Coefficient cystines  1490

Absorbance 280nm  0.893350069957105

Polar residues  6



Literature Information


Literature 1

Title   N-terminus of M2 protein could induce antibodies with inhibitory activity against influenza virus replication.

Pubmed ID   12628550

Reference   FEMS Immunol Med Microbiol. 2003

Author   Liu W, Li H, Chen YH.

DOI   10.1016/S0928-8244(03)00009-9