General Information


DRAVP ID  DRAVPe02669

Peptide Name   C27

Sequence  CGRCLQRACCKYCRLKCRLILFVIF

Sequence Length  25

UniProt ID  No Entry Found 

Taxon ID  None

Source  Synthetic-Contruct

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  RV

Assay  GFP assay

Activity 

  • [Ref:15220414]RV:IC50=22%

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Phosphoprotein

Mechanism  Not Available



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H50C66N15O10S2

Absent amino acids  HMTW

Common amino acids  CRL

Mass  1120.3068

Pl  6.89834384918212

Basic residues  2

Acidic residues  0

Hydrophobic residues  4

Net charge  -0.0853519894995431

Boman Index  1.251

Hydrophobicity  -0.577777777777778

Aliphatic Index  43.33

Half Life 

  •     Mammalian:1.2hours
  •     Yeast:1hours
  •     E.coli:1.1hours

Extinction Coefficient cystines  5500

Absorbance 280nm  4.90936946914899

Polar residues  5



Literature Information


Literature 1

Title   Antiviral drug discovery strategy using combinatorial libraries of structurally constrained peptides.

Pubmed ID   15220414

Reference   J Virol. 2004

Author   Real E, Rain JC, Battaglia V, Jallet C, Perrin P, Tordo N, Chrisment P, D'Alayer J, Legrain P, Jacob Y.

DOI   10.1128/JVI.78.14.7410-7417.2004