General Information


DRAVP ID  DRAVPe02674

Peptide Name   CAP3720-44ser26

Sequence  NQGRHFSGGALIHARFVMTAASCFQ

Sequence Length  25

UniProt ID  P20160 

Taxon ID  None

Source  Antimicrobial peptide CAP37

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  AdV

Assay  Direct time kill assay

Activity 

  • [Ref:19274533]ADV:IC50=Medium

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Membrane

Mechanism  Inhibit Assembly formation



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H38C58N12O12S2

Absent amino acids  HW

Common amino acids  AG

Mass  957.0856

Pl  8.05824184417724

Basic residues  1

Acidic residues  0

Hydrophobic residues  4

Net charge  0.73929063309228

Boman Index  0.654

Hydrophobicity  -0.277777777777777

Aliphatic Index  11.11

Half Life 

  •     Mammalian:1.2hours
  •     Yeast:1hours
  •     E.coli:1.1hours

Extinction Coefficient cystines  1490

Absorbance 280nm  1.55680954765175

Polar residues  5



Literature Information


Literature 1

Title   CAP37-derived antimicrobial peptides have in vitro antiviral activity against adenovirus and herpes simplex virus type 1.

Pubmed ID   19274533

Reference   Curr Eye Res. 2009

Author   Gordon YJ, Romanowski EG, Shanks RM, Yates KA, Hinsley H, Pereira HA.

DOI   10.1080/02713680802714066