General Information


DRAVP ID  DRAVPe02676

Peptide Name   SB105

Sequence  ASLRVRIKKQ

Sequence Length  10

UniProt ID  No Entry Found 

Taxon ID  None

Source  Synthetic-Contruct

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  HSV 1

Assay  Plaque assay

Activity 

  • [Ref:21576348]HSV-1:EC50=0.21¬±0.04µM

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Membrane

Mechanism  Inhibit Replication



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H127C201N36O30S2

Absent amino acids  HMTWV

Common amino acids  KR

Mass  2795.3307

Pl  9.02262439727783

Basic residues  3

Acidic residues  1

Hydrophobic residues  14

Net charge  1.74308009626448

Boman Index  0.79

Hydrophobicity  0.92

Aliphatic Index  120.4

Half Life 

  •     Mammalian:1.2hours
  •     Yeast:1hours
  •     E.coli:1.1hours

Extinction Coefficient cystines  5500

Absorbance 280nm  1.96756684280683

Polar residues  11



Literature Information


Literature 1

Title   Reduced HIV transmission at subsequent pregnancy in a resource-poor setting.

Pubmed ID   21576348

Reference   Trop Doct. 2011

Author   Gumbo FZ, Kandawasvika GQ, Duri K, Mapingure MP, Kurewa NE, Nathoo K, Rusakaniko S, Chirenje MZ, Stray-Pedersen B.

DOI   10.1258/td.2011.100458