General Information


DRAVP ID  DRAVPe02679

Peptide Name   NDVFz20-L5,12A peptide

Sequence  ALDKAEESNSKADKVNVKLT

Sequence Length  20

UniProt ID  P12572 

Taxon ID  None

Source  NDV fusion protein (HR2)

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  NDV

Assay  Fusion assay

Activity 

  • [Ref:9527912]NDV:IC50=35µM

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Membrane

Mechanism  Inhibit Fusion



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H163C280N49O53S0

Absent amino acids  DHMW

Common amino acids  KA

Mass  3795.3026

Pl  8.43035335540771

Basic residues  6

Acidic residues  5

Hydrophobic residues  16

Net charge  0.766758518192617

Boman Index  0.999

Hydrophobicity  -0.245714285714285

Aliphatic Index  108.86

Half Life 

  •     Mammalian:20hours
  •     Yeast:15hours
  •     E.coli:18hours

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  19



Literature Information


Literature 1

Title   The role of leucine residues in the structure and function of a leucine zipper peptide inhibitor of paramyxovirus (NDV) fusion.

Pubmed ID   9527912

Reference   Virology. 1998

Author   Young JK, Hicks RP, Wright GE, Morrison TG.

DOI   10.1006/viro.1998.9044