General Information


DRAVP ID  DRAVPe02685

Peptide Name   HRB2

Sequence  FNVALDQVFESIENSQALVDQSNRILSSAE

Sequence Length  30

UniProt ID  Q6WB98 

Taxon ID  None

Source  hMPV fusion (F) protein

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  hMPV

Assay  RT PCR

Activity 

  • [Ref:17967906]hMPV:IC50=>9,000nM

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Membrane

Mechanism  Inhibit Virus entry



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H72C118N21O24S0

Absent amino acids  HKMTW

Common amino acids  VLS

Mass  1680.8566

Pl  4.25288677215576

Basic residues  1

Acidic residues  3

Hydrophobic residues  5

Net charge  -2.03304974640201

Boman Index  1.031

Hydrophobicity  -0.566666666666666

Aliphatic Index  123.33

Half Life 

  •     Mammalian:20hours
  •     Yeast:15hours
  •     E.coli:18hours

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  10



Literature Information


Literature 1

Title   Identification and evaluation of a highly effective fusion inhibitor for human metapneumovirus.

Pubmed ID   17967906

Reference   Antimicrob Agents Chemother. 2008

Author   Deffrasnes C, Hamelin ME, Prince GA, Boivin G.

DOI   10.1128/AAC.00793-07