General Information


DRAVP ID  DRAVPe02687

Peptide Name   VP4-peptide

Sequence  CNIAPASIVSRNIVYTRAQPNQDIA

Sequence Length  25

UniProt ID  P08713 

Taxon ID  None

Source  BRV capsid protein-VP4

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  BRV

Assay  Plaque assay

Activity 

  • [Ref:9682337]BRV:IC50=200µg/ml

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Membrane

Mechanism  Inhibit Virus entry



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H176C298N50O59S0

Absent amino acids  HKMFTW

Common amino acids  IANV

Mass  4078.57939999999

Pl  4.65689830780029

Basic residues  4

Acidic residues  6

Hydrophobic residues  15

Net charge  -2.22942201893517

Boman Index  0.978

Hydrophobicity  -0.194594594594594

Aliphatic Index  134.32

Half Life 

  •     Mammalian:20hours
  •     Yeast:15hours
  •     E.coli:18hours

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  22



Literature Information


Literature 1

Title   Inhibition of rotavirus infection in vitro and in vivo by a synthetic peptide from VP4.

Pubmed ID   9682337

Reference   Vaccine. 1998

Author   Ijaz MK, Nur-E-Kamal MS, Dar FK, Uduman S, Redmond MJ, Attah-Poku SK, Dent D, Babiuk LA.

DOI   10.1016/s0264-410x(97)00298-3