General Information


DRAVP ID  DRAVPe02688

Peptide Name   HCVc16-36

Sequence  NRRPQDVKFPGGGQIVGGVYL

Sequence Length  21

UniProt ID  P26663 

Taxon ID  None

Source  HCV core protein

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  HCV

Assay  Luciferase assay

Activity 

  • [Ref:20862261HCV:IC50=High

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Membrane

Mechanism  Inhibit Replication



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H76C116N27O23S1

Absent amino acids  HMW

Common amino acids  GVR

Mass  1829.0055

Pl  8.24964847564697

Basic residues  3

Acidic residues  2

Hydrophobic residues  2

Net charge  0.755791548336709

Boman Index  1.306

Hydrophobicity  -2.10666666666666

Aliphatic Index  0

Half Life 

  •     Mammalian:48.0mins
  •     Yeast:42mins
  •     E.coli:36mins

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  13



Literature Information


Literature 1

Title   Hepatitis C virus core-derived peptides inhibit genotype 1b viral genome replication via interaction with DDX3X.

Pubmed ID   20862261

Reference   PLoS One. 2010

Author   Sun C, Pager CT, Luo G, Sarnow P, Cate JH.

DOI   10.1371/journal.pone.0012826