General Information


DRAVP ID  DRAVPe02691

Peptide Name   Mucroporin

Sequence  LFGLIPSLIGGLVSAFK

Sequence Length  17

UniProt ID  B9UIY3 

Taxon ID  172552 

Source  Scorpion venom

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  MV,SARS-CoV,IAV

Assay  Plaque assay

Activity 

  • [Ref:21620914]MV:EC50=3.52µm in Vero cells,SARS-CoV:EC50=7.12µM in MDCK cells, IAV:EC50=1.03µM inMDCK cells

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Membrane

Mechanism  Inhibit Replication



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H25C37N7O7S2

Absent amino acids  HMTWV

Common amino acids  LGIF

Mass  629.7492

Pl  8.04528369903564

Basic residues  1

Acidic residues  0

Hydrophobic residues  3

Net charge  0.738301631993281

Boman Index  0.875

Hydrophobicity  -0.166666666666666

Aliphatic Index  0

Half Life 

  •     Mammalian:1.2hours
  •     Yeast:1hours
  •     E.coli:1.1hours

Extinction Coefficient cystines  1490

Absorbance 280nm  2.36602126687894

Polar residues  3



Literature Information


Literature 1

Title   Virucidal activity of a scorpion venom peptide variant mucroporin-M1 against measles, SARS-CoV and influenza H5N1 viruses.

Pubmed ID   21620914

Reference   Peptides. 2011

Author   Li Q, Zhao Z, Zhou D, Chen Y, Hong W, Cao L, Yang J, Zhang Y, Shi W, Cao Z, Wu Y, Yan H, Li W.

DOI   10.1016/j.peptides.2011.05.015