General Information


DRAVP ID  DRAVPe02697

Peptide Name   P4

Sequence  TDAVDCSQNPLAELKCSVKSF

Sequence Length  21

UniProt ID  P59594 

Taxon ID  694009 

Source  S1 of SARS-CoV spike protein

Validation   Experimentally Validated



Origin Information


Gene Name/ID  S

GenBank  Not Available

Amino Acid position  273–293

Domain Accession ID  Not Available

Nucleotide sequence ID  AY274119.3 

Molecular Type  Genomic RNA

Chromosomal Position  Chromosome:21,492 - 25,259



Activity Information


Target Organism  SARS-CoV

Assay  Syncitia assay

Activity 

  • [Ref:15811330]SARS-CoV:IC50=inhibiti SRS-CoV in HEK293T cells

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Membrane

Mechanism  Inhibit Virus entry



Structure Information


PDB ID  1WNC  1ZV7 

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H38C56N14O12S2

Absent amino acids  RNWMNYOU

Common amino acids  CS

Mass  983.0831

Pl  6.89834384918212

Basic residues  2

Acidic residues  0

Hydrophobic residues  3

Net charge  -0.0853519894995431

Boman Index  0.832

Hydrophobicity  -0.433333333333333

Aliphatic Index  32.22

Half Life 

  •     Mammalian:1.2hours
  •     Yeast:1hours
  •     E.coli:1.1hours

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  6



Literature Information


Literature 1

Title   Synthetic peptides derived from SARS coronavirus S protein with diagnostic and therapeutic potential.

Pubmed ID   15811330

Reference   FEBS Lett. 2005

Author   Lu W, Wu XD, Shi MD, Yang RF, He YY, Bian C, Shi TL, Yang S, Zhu XL, Jiang WH, Li YX, Yan LC, Ji YY, Lin Y, Lin GM, Tian L, Wang J, Wang HX, Xie YH, Pei G, Wu JR, Sun B.

DOI    10.1016/j.febslet.2005.02.070