General Information


DRAVP ID  DRAVPe02698

Peptide Name   P5

Sequence  KGIYQTSNFRVVPSGDVVRF

Sequence Length  20

UniProt ID  P59594 

Taxon ID  694009 

Source  S1 of SARS-CoV spike protein

Validation   Experimentally Validated



Origin Information


Gene Name/ID  S

GenBank  Not Available

Amino Acid position  297–316

Domain Accession ID  Not Available

Nucleotide sequence ID  AY274119.3 

Molecular Type  Genomic RNA

Chromosomal Position  Chromosome:21,492 - 25,259



Activity Information


Target Organism  SARS-CoV

Assay  Syncitia assay

Activity 

  • [Ref:15811330]SARS-CoV:IC50=inhibiti SRS-CoV in HEK293T cells

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Membrane

Mechanism  Inhibit Virus entry



Structure Information


PDB ID  1WNC  1ZV7 

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H81C127N29O26S0

Absent amino acids  ANDCMWYOU

Common amino acids  FV

Mass  1943.0848

Pl  6.75533695220947

Basic residues  4

Acidic residues  3

Hydrophobic residues  4

Net charge  -0.148701214402215

Boman Index  1.459

Hydrophobicity  -1.85999999999999

Aliphatic Index  71.33

Half Life 

  •     Mammalian:1.1hours
  •     Yeast:1hours
  •     E.coli:1hours

Extinction Coefficient cystines  1490

Absorbance 280nm  0.766821911220756

Polar residues  11



Literature Information


Literature 1

Title   Synthetic peptides derived from SARS coronavirus S protein with diagnostic and therapeutic potential.

Pubmed ID   15811330

Reference   FEBS Lett. 2005

Author   Lu W, Wu XD, Shi MD, Yang RF, He YY, Bian C, Shi TL, Yang S, Zhu XL, Jiang WH, Li YX, Yan LC, Ji YY, Lin Y, Lin GM, Tian L, Wang J, Wang HX, Xie YH, Pei G, Wu JR, Sun B.

DOI    10.1016/j.febslet.2005.02.070