General Information


DRAVP ID  DRAVPe02699

Peptide Name   P6

Sequence  TKFPSVYAWERKKISNCVAD

Sequence Length  20

UniProt ID  P59594 

Taxon ID  694009 

Source  S1 of SARS-CoV spike protein

Validation   Experimentally Validated



Origin Information


Gene Name/ID  S

GenBank  Not Available

Amino Acid position  332–351

Domain Accession ID  Not Available

Nucleotide sequence ID  AY274119.3 

Molecular Type  Genomic RNA

Chromosomal Position  Chromosome:21,492 - 25,259



Activity Information


Target Organism  SARS-CoV

Assay  Syncitia assay

Activity 

  • [Ref:15811330]SARS-CoV:IC50=inhibiti SRS-CoV in HEK293T cells

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Membrane

Mechanism  Inhibit Virus entry



Structure Information


PDB ID  1WNC  1ZV7 

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H79C127N23O21S0

Absent amino acids  CQMNOU

Common amino acids  K

Mass  1753.0103

Pl  8.74786014556885

Basic residues  2

Acidic residues  1

Hydrophobic residues  7

Net charge  0.761903075263511

Boman Index  1.113

Hydrophobicity  -0.406666666666666

Aliphatic Index  117.33

Half Life 

  •     Mammalian:5.5hours
  •     Yeast:10hours
  •     E.coli:6hours

Extinction Coefficient cystines  5500

Absorbance 280nm  3.13746017350839

Polar residues  8



Literature Information


Literature 1

Title   Synthetic peptides derived from SARS coronavirus S protein with diagnostic and therapeutic potential.

Pubmed ID   15811330

Reference   FEBS Lett. 2005

Author   Lu W, Wu XD, Shi MD, Yang RF, He YY, Bian C, Shi TL, Yang S, Zhu XL, Jiang WH, Li YX, Yan LC, Ji YY, Lin Y, Lin GM, Tian L, Wang J, Wang HX, Xie YH, Pei G, Wu JR, Sun B.

DOI    10.1016/j.febslet.2005.02.070