General Information


DRAVP ID  DRAVPe02705

Peptide Name   SB105

Sequence  ASLRVRIKKQ

Sequence Length  10

UniProt ID  No Entry Found 

Taxon ID  None

Source  Synthetic Construct

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  HCMV,MCMV

Assay  EGFP expression

Activity 

  • [Ref:20083141]HCMV:IC50=0.23 μM in HELFs cells,MCMV:IC50=0.67μM in NIH3T3 cells,The IC50 and IC90 concentrations for HCMV replication were 0.22 and 0.77 μM for SB105

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Membrane

Mechanism  Inhibit the replication of GCV-resistant strains of HCMV



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H72C127N17O15S0

Absent amino acids  CDEFGHIMNPQRSW

Common amino acids  AKLTVY

Mass  1488.89

Pl  10.1768663406372

Basic residues  4

Acidic residues  0

Hydrophobic residues  8

Net charge  3.75510660919429

Boman Index  1.117

Hydrophobicity  0.66

Aliphatic Index  156.92

Half Life 

  •     Mammalian:1.3 hours
  •     Yeast:1.1 hours
  •     E.coli:1.2 hours

Extinction Coefficient cystines  1490

Absorbance 280nm  17396

Polar residues  5



Literature Information


Literature 1

Title   Peptide-derivatized dendrimers inhibit human cytomegalovirus infection by blocking virus binding to cell surface heparan sulfate.

Pubmed ID   20083141

Reference   Antiviral Res. 2010

Author   Luganini A, Giuliani A, Pirri G, Pizzuto L, Landolfo S, Gribaudo G.

DOI   10.1016/j.antiviral.2010103