General Information


DRAVP ID  DRAVPe02706

Peptide Name   SB105_A10

Sequence  ASLRVRIKK

Sequence Length  9

UniProt ID  No Entry Found 

Taxon ID  None

Source  Synthetic Construct

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  HCMV,MCMV

Assay  EGFP expression

Activity 

  • [Ref:20083141]HCMV:IC50=0.25 μM in HELFs cells,IC50= 0.98 μM in NIH3T3 cells,The IC50 and IC90 concentrations for HCMV replication were 0.29 and 14 μM

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Membrane

Mechanism  Inhibit the replication of GCV-resistant strains of HCMV



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H47C74N14O10S2

Absent amino acids  DEFGHIKMPQSTY

Common amino acids  ACLNRVW

Mass  1077.32

Pl  8.7210254

Basic residues  1

Acidic residues  0

Hydrophobic residues  7

Net charge  0.740289634091281

Boman Index  0.964

Hydrophobicity  1.7777

Aliphatic Index  130

Half Life 

  •     Mammalian:1.2 hours
  •     Yeast:1 hours
  •     E.coli:1.1 hours

Extinction Coefficient cystines  5500

Absorbance 280nm  5.10524509167814

Polar residues  2



Literature Information


Literature 1

Title   Peptide-derivatized dendrimers inhibit human cytomegalovirus infection by blocking virus binding to cell surface heparan sulfate.

Pubmed ID   20083141

Reference   Antiviral Res. 2010

Author   Luganini A, Giuliani A, Pirri G, Pizzuto L, Landolfo S, Gribaudo G.

DOI   10.1016/j.antiviral.2010103