General Information


DRAVP ID  DRAVPe02713

Peptide Name   SB112

Sequence  QKKIRWRLSA

Sequence Length  10

UniProt ID  No Entry Found 

Taxon ID  None

Source  Synthetic Construct

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  HCMV

Assay  EGFP expression

Activity  No MIC is available in the Article

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Membrane

Mechanism  Inhibit the replication of GCV-resistant strains of HCMV



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H152C241N41O43S0

Absent amino acids  CIMQW

Common amino acids  ADEFGHKLNPRSTVY

Mass  1285.56

Pl  9.69625453948974

Basic residues  5

Acidic residues  2

Hydrophobic residues  12

Net charge  1.82207679832579

Boman Index  0.884

Hydrophobicity  -0.13

Aliphatic Index  91

Half Life 

  •     Mammalian:100 hours
  •     Yeast:60 hours
  •     E.coli:90 hours

Extinction Coefficient cystines  1490

Absorbance 280nm  0.44493499440009

Polar residues  18



Literature Information


Literature 1

Title   Peptide-derivatized dendrimers inhibit human cytomegalovirus infection by blocking virus binding to cell surface heparan sulfate.

Pubmed ID   20083141

Reference   Antiviral Res. 2010

Author   Luganini A, Giuliani A, Pirri G, Pizzuto L, Landolfo S, Gribaudo G.

DOI   10.1016/j.antiviral.2010103