General Information


DRAVP ID  DRAVPe02731

Peptide Name   -

Sequence  CSTTNATWC

Sequence Length  9

UniProt ID  No Entry Found 

Taxon ID  None

Source  Synthetic-Construct(phage display selection of cyclic nonapeptides)

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  SNV

Assay  Focus reduction assay

Activity 

  • [Ref:18391034]SNV:IC50=36%, p Value=0.6621 inhibition in Vero E6 cells

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Membrane

Mechanism  Inhibit Virus Entry



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Cyclic

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H92C145N29O18S0

Absent amino acids  FHIKLMV

Common amino acids  CS

Mass  1963.33

Pl  11.7443506240844

Basic residues  7

Acidic residues  0

Hydrophobic residues  5

Net charge  5.84324979874788

Boman Index  1.591

Hydrophobicity  -1.26

Aliphatic Index  52

Half Life 

  •     Mammalian:1.1 hours
  •     Yeast:30 mins
  •     E.coli:54 mins

Extinction Coefficient cystines  1490

Absorbance 280nm  0.758913000251002

Polar residues  10



Literature Information


Literature 1

Title   Multivalent presentation of antihantavirus peptides on nanoparticles enhances infection blockade.

Pubmed ID   18391034

Reference   Antimicrob Agents Chemother. 2008

Author   Hall PR, Hjelle B, Brown DC, Ye C, Bondu-Hawkins V, Kilpatrick KA, Larson RS.

DOI    10.1128/AAC1415-07