General Information


DRAVP ID  DRAVPe02734

Peptide Name   -

Sequence  CVMSKHQHC

Sequence Length  9

UniProt ID  No Entry Found 

Taxon ID  None

Source  Synthetic-Construct(phage display selection of cyclic nonapeptides)

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  SNV

Assay  Focus reduction assay

Activity 

  • [Ref:18391034]SNV:IC50=30%, p Value=0.4882 inhibition in Vero E6 cells

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Membrane

Mechanism  Inhibit Virus Entry



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Cyclic

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H174C294N47O56S1

Absent amino acids  FILTW

Common amino acids  CS

Mass  1072.28

Pl  8.8860649

Basic residues  7

Acidic residues  6

Hydrophobic residues  13

Net charge  0.755691985870815

Boman Index  1.222

Hydrophobicity  -0.75

Aliphatic Index  100.29

Half Life 

  •     Mammalian:20 hours
  •     Yeast:15 hours
  •     E.coli:18 hours

Extinction Coefficient cystines  1490

Absorbance 280nm  0.373287141262602

Polar residues  22



Literature Information


Literature 1

Title   Multivalent presentation of antihantavirus peptides on nanoparticles enhances infection blockade.

Pubmed ID   18391034

Reference   Antimicrob Agents Chemother. 2008

Author   Hall PR, Hjelle B, Brown DC, Ye C, Bondu-Hawkins V, Kilpatrick KA, Larson RS.

DOI    10.1128/AAC1415-07