General Information


DRAVP ID  DRAVPe02740

Peptide Name   -

Sequence  CQTTNWNTC

Sequence Length  9

UniProt ID  No Entry Found 

Taxon ID  None

Source  Synthetic-Construct(phage display selection of cyclic nonapeptides)

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  SNV

Assay  Focus reduction assay

Activity 

  • [Ref:18391034]SNV:IC50=74%, p Value=0.4673 inhibition in Vero E6 cells

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Membrane

Mechanism  Inhibit Virus Entry



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Cyclic

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  H180C273N45O52S0

Absent amino acids  FHIKLMV

Common amino acids  CS

Mass  1070.16

Pl  4.65684146881103

Basic residues  4

Acidic residues  6

Hydrophobic residues  14

Net charge  -2.23142002093317

Boman Index  1.3

Hydrophobicity  -0.73125

Aliphatic Index  109.69

Half Life 

  •     Mammalian:20 hours
  •     Yeast:15 hours
  •     E.coli:18 hours

Extinction Coefficient cystines  13980

Absorbance 280nm  3.56687739478949

Polar residues  18



Literature Information


Literature 1

Title   Multivalent presentation of antihantavirus peptides on nanoparticles enhances infection blockade.

Pubmed ID   18391034

Reference   Antimicrob Agents Chemother. 2008

Author   Hall PR, Hjelle B, Brown DC, Ye C, Bondu-Hawkins V, Kilpatrick KA, Larson RS.

DOI    10.1128/AAC1415-07