DRAVP ID  DRAVPa0033

Peptide Name   Sequence 6 from Patent US 7244710

Sequence  VPKXCKPV

Sequence Length  8

Source  Synthetic construct

Target Organism  Herpesvirus,HIV

Patent Type  Granted Patent

Publication Date  2007-07-17

Patent No  US 7244710 B2

Family Info  FR 1456903 A, ES 323291 A1, SU 622426 A3

Patent Title  Treatment Of Ophthalmic Infections Using Antimicrobial Peptides

Comment  The peptide is formed by two PKV peptides which linked by a linker(disulfide bond between residues 4 and 5), the 'X' at position 4 indicates Penicillamine.The peptide could treat viral ophthalmic infection of the invention caused by Poxvirus, Herpesvirus, Adenovirus, Paramyxovirus and Human Immunodeficiency virus, especially Herpesvirus and Human Immunodedeficiency virus(HIV), the key species in Herpesvirus are Herpes simplex virus, Herpes zoster virus, Epstein-Barr virus, Cytomegalovirus.The possible mechanism of action is inhibiting HIV-p24 expression in HIV infected cells or HIV transcription.

Abstract  The present invention discloses a method of treating an ophthalmic infection by administering to a vertebrate inflicted with the ophthalmic infection an ophthalmologically effective amount of an antimicrobial peptide which is derived from alpha-melanocyte-stimulating hormone (α-MSH) and biologically functional equivalents thereof. Specifically, the antimicrobial peptides derived from alpha-melanocyte-stimulating hormone (α-MSH) include α-MSH (1–13) which is SYSMEHFRWGKPV, α-MSH (4–10) which is MEHFRWG, α-MSH (6–13) which is HFRWGKPV, α-MSH (11–13) which is KPV, and a KPV dimer. The ophthalmic infection can be caused by a microorganism which include a bacteria, a fungi or a virus. The vertebrate includes a bird and a mammal. The antimicrobial peptide has anti-bacterial, antifungal, and antiviral property and therefore can be administered at the onset of the ophthalmic infection before the microorganism causing the infection is determined as well as thereafter.