Patent Information


DRAVP ID  DRAVPa0046

Peptide Name   Sequence 8 from Patent US 2009/0264344 A1

Sequence  GICICICGYGICRCICGR

Sequence Length  18

Source  Synthetic construct

Target Organism  HIV-1,HSV-1,HSV-2

Patent Type  Patent Application

Publication Date  2009-10-22

Patent No  US 2009/0264344 A1

Family Info  US 2005/0272645 A1, WO 2006/052637 A1, US 7314858 B2, US 2009/0264344 A1, US 7718610 B2

Patent Title  Retrocyclins: Antiviral and Antimicrobial Peptides

Comment  The peptide is potently active against both X4 and R5 strains of HIV-1 by inhibiting virus replication.

Abstract  Retrocyclin peptides are small antimicrobial agents with potent activity against bacteria and viruses. The peptides are nonhemolytic, and exhibit minimal in vitro cytotoxicity. A pharmaceutical composition comprising retrocyclin as an active agent is administered therapeutically to a patient suffering from a bacterial and/or viral infection, or to an individual facing exposure to a bacterial and/or viral infection, especially one caused by the HIV-1 retrovirus or other sexually-transmitted pathogens.