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DRAVP ID DRAVPa0321
Peptide Name Sequence 16 from Patent US 7790171 B1
Sequence KETWEXWWXX
Sequence Length 10
Source Synthetic construct
Target Organism HIV
Patent Type Granted Patent
Publication Date 2010-09-07
Patent No US 7790171 B1
Family Info WO 2002/015661 A2, AU 2001/092153 A, WO 2002/015661 A8, WO 2002/015661 A3, EP 1311538 A2, EP 1311538 B1, AT 420103 T, DE 60137340 D1, US 7790171 B1, US 2011/0064793 A1
Patent Title Antiviral peptides obtained from the tryptophan-rich hydrophobic cluster of the HIV-1 reverse transcriptase
Comment The 'X' at position 6 indicates Thr or Ala, the 'X' at position 10 indicates Glu or Asp,and the 'X' at position 9 indicates Thr,Ala,Val or Ile.
Abstract The invention is drawn to a novel class of drugs directed against HIV, comprising a peptide or analog comprising a decapeptide, said decapeptide containing (from N-terminus to the C-terminus) a basic amino acid in position 1, an acidic amino acid in positions 2 and 5, and a tryptophan in positions 4, 7, and 8, and to a method of treatment of HIV infections, in particular multidrug-resistant HIV infections.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.