DRAVP ID  DRAVPa0992

Peptide Name   Sequence 7 from Patent US 7432045 B2

Sequence  RQIKIWFPNRRMKWKKPGYAGAVVNDL

Sequence Length  27

Source  Synthetic construct

Target Organism  HSV,HIV,Influenza A Virus,H5 Avian Influenza Virus

Patent Type  Granted Patent

Publication Date  2008-10-07

Patent No  US 7432045 B2

Family Info  WO 2005/060541 A2, US 2005/0203024 A1, WO 2005/060541 A3, US 7432045 B2

Patent Title  Method of inhibiting influenza infection with antiviral peptides

Comment  The antiviral peptide showS antiviral activity against a wide range of enveloped and non-enveloped viruses. Examples of enveloped viruses include, but are not limited to, human immunodeficiency virus (HIV), vesicular stomatitis virus (VSV), herpes simplex viruses (HSV-1 and HSV-2), and other herpes viruses, for example, varicella-zoster virus (VZV), EBV, equine herpes virus (EHV), influenza virus and human cytomegalovirus (HCMV). Examples of non-enveloped viruses include, but are not limited to, papilloma virus (PV) and adenoviruses (AV).The peptide inhibits HSV-1 by blocking entry(IC50=9-12 μm) and antifree virus activity(IC50=6 μm).

Abstract  This invention relates to peptides having antiviral properties. The antiviral peptides comprise membrane transiting peptides, and active fragments and derivatives of such peptides. The antiviral peptides exhibit activity against a broad spectrum of viruses, including enveloped and non-enveloped viruses, and are used in pharmaceutical compositions to prevent and/or treat viral infections.