DRAVP ID  DRAVPa1024

Peptide Name   Sequence 41 from Patent US 7432045 B2

Sequence  GRKKRRQXXRC

Sequence Length  11

Source  Synthetic construct

Target Organism  HSV,HIV,Influenza A Virus,H5 Avian Influenza Virus

Patent Type  Granted Patent

Publication Date  2008-10-07

Patent No  US 7432045 B2

Family Info  WO 2005/060541 A2, US 2005/0203024 A1, WO 2005/060541 A3, US 7432045 B2

Patent Title  Method of inhibiting influenza infection with antiviral peptides

Comment  The 'X' at position 8 and 9 represents Norleucine.The antiviral peptide showS antiviral activity against a wide range of enveloped and non-enveloped viruses. Examples of enveloped viruses include, but are not limited to, human immunodeficiency virus (HIV), vesicular stomatitis virus (VSV), herpes simplex viruses (HSV-1 and HSV-2), and other herpes viruses, for example, varicella-zoster virus (VZV), EBV, equine herpes virus (EHV), influenza virus and human cytomegalovirus (HCMV). Examples of non-enveloped viruses include, but are not limited to, papilloma virus (PV) and adenoviruses (AV).

Abstract  This invention relates to peptides having antiviral properties. The antiviral peptides comprise membrane transiting peptides, and active fragments and derivatives of such peptides. The antiviral peptides exhibit activity against a broad spectrum of viruses, including enveloped and non-enveloped viruses, and are used in pharmaceutical compositions to prevent and/or treat viral infections.